Here I will list all the weaknesses I have found so far for each type of enemy. Which weapons work best on them, and which weapons can easily coat some of the most annoying creatures before they end your Doom Marine military career for good. Get my advice under each entry. Some enemies are so easy that they don't need a lot of explanation. Other? They need a lot more.
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Zombies / Mecha Zombies
- Little fodder that exists for agricultural resources. Use the Chainsaw for ammo, Glory Kill for health, and Flame Belch for armor.
- Double dash in a standard zombie to put them in a Glory Kill state.
- Mecha Zombies is much more difficult. They are a good target for the chainsaw.
Leprechaun
- Guns with bullets are particularly good. The heavy cannon will stun a sprite and bring him to glory faster.
Blaster Soldier / Shield Soldier
- The shotgun can instantly fail a Blaster Soldier.
- Shield blasters are weak for the Plasma Rifle. Overloading their shield will instantly kill them and stun nearby enemies.
- Blood Punch will instantly shatter a Shield Soldier.
Gargoyle
- Like Imps, bullet weapons will defeat gargoyles. Put them out of action as they fly to instantly put them in a Glory Kill state.
Lost soul
- Ice Bomb instantly kills Lost Souls.
- Gun explosions will throw Lost Souls upside down and trigger them like a grenade - like a Cueball.
Maykr Drones
- Use the Precision Heavy Cannon mod to instantly kill Maykr drones with a headshot. Use the Rune to idle yourself in the air!
- Their heads are their only weakness. Their bodies absorb an absurd amount of damage.
- Headshots will cause them to generate ammo, health, and armor.
Arachnotron
- Use the precision heavy cannon to easily destroy the turret on the back of the Arachnotron.
Cacodemon
- The Charged Ballista can instantly kill a Cacodemon at long range.
- Frag Grenades can be used to instantly put them into a Glory Kill state. Use it to avoid spending mid-range ammo. You can also use sticky grenades with the shotgun.
Carcass
- The Plasma Rifle can overload any shields the Hulk spawns, killing nearby enemies.
- Blood Punch will also instantly destroy their shields.
- The carcass will only attack if you get close to it. Otherwise, it harmlessly generates shields from afar.
Cyber Mancubus
- Blood Punch shatters the Cyber Mancubus armor, leaving them exposed. Normal attacks will work on them.
- Combine Blood Punch and a Heat Blast loaded with the Plasma Rifle to quickly destroy a Cyber Mancubus.
- You cannot destroy Cyber Mancubus arm cannons.
- Killing Chest Glory detonates Cyber Mancubus.
- Very easy targets for Double Frag Grenades.
Dread Knight / Hell Knight
- Use the Chaingun to stun the Dread Knight faster.
Mancubus
- Use the precision heavy cannon to destroy the hand cannons. This deactivates flamethrowers and weakens blasters.
- Like Cyber Mancubus, a chest Glory Kill will detonate the Mancubus.
- An easy target for frag grenades. Even better if you have the Frag Grenade dual upgrade.
Elemental of Pain
- Use ice bombs to instantly kill the lost souls it spawns.
- The Ballista Arbalest Mod can quickly kill Pain Elemental with three charged hits.
- They are also weak compared to the standard Ballista.
Pinky
- Save your Blood Punch for the Pinky Demons. He kills them instantly every time.
- The Super Shotgun can insta-kill a Pinky by shooting in the back within range of a white point.
- Use the ice bomb to easily stop and maneuver behind it for a simple kill.
Prowler
- Ice Bomb will stop its teleportation ability.
- Lock-On Burst is the easiest way to kill a Prowler.
Revenant
- Revenant staggers faster when fired in the air.
- Use the precision heavy cannon to destroy shoulder launchers to deactivate bolt-action rockets.
- You can break the rocket lock by rushing or double jumping.
Spectre
- The ice bomb will deactivate the camouflage. When the stealth is broken, lockable weapons will work on it.
- Again, the Super Shotgun can kill a Specter with a single hit at close range.
Whiplash
- The ice bomb will prevent it from slipping.
- Lock-On Burst is a great way to kill them quickly and beat their unpredictable movement.
Archvile
- Use the Super Shotgun at close range to make them wobble during the summoning. It will kill incoming demons.
- Use Blood Punch to smash their fire shield.
- Save the BFG / Crucible sword to kill them as quickly as possible.
Hell baron
- They are fast. Use ice bombs to slow them down and unlock debuff upgrade.
- Use the Movable Turret - Chaingun will put them in a Glory Kill state faster.
- Otherwise, use the Crucible sword.
Doom hunter
- Aim for the sled first - use the Ballista to accurately shoot the sled. When it is destroyed, you permanently deactivate its rockets / shield.
- Blood Punch deals bonus damage to the sled. Save your blood shot for the sled.
- Use the Plasma Rifle to deactivate the shield, then use the Lock-On Burst Rocket Launcher to damage it extremely quickly.
Marauder
- Extremely deadly enemies. Use the Super Shotgun and wait halfway - shoot when their eyes glow green.
- While they're failing, quickly swap with the BFG or Unmaykr to kill them quickly. While it falters, a BFG shot will kill them instantly. The Unmaykr kills them in two weaknesses.
- Kill the dog they spawn as soon as possible.
- Keep moving until all other enemies are taken care of, they clash against the Marauder 1 on 1. They cannot hit you from long range.
Tyrant
- Tyrants are very slow and turn slowly. Use Dual Frag Grenades, Ice Bomb, and Lockdown Hatch to kill them quickly. Ballista also helps.
- Stay back and use double dashes to avoid his attacks. If you keep moving, the Tyrant is not a very difficult enemy.